- Pigmented macules on lips, palms and soles: Peutz-Jegers
- Cafe au lait spots: Neurofibromatosis
- Spider angiomata: liver cirrhosis
- Acanthosis nigricans: neoplasm
- Fragile skin and keloids: Ehlers Danlos
- Webbed neck, purpura and skin nodules: Turner's syndrome
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