Paraneoplastic Syndromes

Etiology

(++ = strong association; + = reported association) Endocrine Cushing's syndrome Small-cell lung cancer: ++ Non-small-cell lung cancer: + Gonadotropin excess Small-cell lung cancer: ++ Non-small-cell lung cancer: + Gastrointestinal cancers: + Gestational trophoblastic disease: + Renal cell cancer: + Carcinoid: + Hypercalcemia Small-cell lung cancer: ++ Non-small-cell lung cancer: + Breast cancer: + Multiple myeloma: + Lymphoma: + Prostate cancer: + Hyperthyroidism Gestational trophoblastic disease: + Hypoglycemia Gastrointestinal cancers: + Hepatocellular cancer: + SIADH Small-cell lung cancer: ++ Non-small-cell lung cancer: + Neuromuscular Dermatomyositis/polymyositis Small-cell lung cancer: ++ Non-small-cell lung cancer: + Breast cancer: + Gastrointestinal cancers: ++ Ovarian cancer: + Myeloproliferative disease: + Lambert-Eaton syndrome Small-cell lung cancer: ++ Breast cancer: + Gastrointestinal cancers: + Ovarian cancer: + Sensorimotor peripheral neuropathy Small-cell lung cancer: ++ Non-small-cell lung cancer: + Stiff man syndrome Breast cancer: + Ovarian cancer: + Subacute cerebellar degeneration Small-cell lung cancer: ++ Non-small-cell lung cancer: + Gastrointestinal cancers: + Lymphoma: + Ovarian cancer: + Skin Acanthosis nigricans Non-small-cell lung cancer: + Breast cancer: + Gastrointestinal cancers: + Carcinoid: + Prostate cancer: + Myeloproliferative disease: + Dermatomyositis Small-cell lung cancer: ++ Non-small-cell lung cancer: + Breast cancer: + Gastrointestinal cancers: ++ Ovarian cancer: + Myeloproliferative disease: + Sweet's syndrome Non-small-cell lung cancer: + Breast cancer: + Gastrointestinal cancers: + Lymphoma: ++ Renal cell cancer: + Ovarian cancer: + Prostate cancer: + Myeloproliferative disease: ++ Hematologic Coagulopathy Breast cancer: + Lymphoma: + Renal cell cancer: + Carcinoid: + Prostate cancer: + Myeloproliferative disease: + Eosinophilia Lymphoma: ++ Erythrocytosis Hepatocellular cancer: + Renal cell cancer: + Ovarian cancer: + Adrenocortical tumors: + Cerebellar hemangioblastomas: + Pure red cell aplasia Non-small-cell lung cancer: + Breast cancer: + Gastrointestinal cancers: + Lymphoma: + Thymoma: ++ Thrombocytosis Small-cell lung cancer: + Non-small-cell lung cancer: + Breast cancer: + Multiple myeloma: + Gastrointestinal cancers: + Hepatocellular cancer: + Gestational trophoblastic disease: + Lymphoma: + Renal cell cancer: + Carcinoid: + Thymoma: + Ovarian cancer: + Prostate cancer: + Myeloproliferative disease: + Adrenocortical tumors: + Cerebellar hemangioblastomas: + Fever Small-cell lung cancer: + Non-small-cell lung cancer: + Breast cancer: + Multiple myeloma: + Gastrointestinal cancers: + Hepatocellular cancer: + Gestational trophoblastic disease: + Lymphoma: + Renal cell cancer: + Carcinoid: + Thymoma: + Ovarian cancer: + Prostate cancer: + Myeloproliferative disease: + Adrenocortical tumors: + Cerebellar hemangioblastomas: + Amyloidosis Multiple myeloma: + Lymphoma: + Renal cell cancer: +