2 for 1 Deal... Salmonella typhi and Ceftriaxone


Two unusual things "live" in the gallbladder. One is S. typhi, which is a motile gram negative rod who "swims" upstream from the colon to the gallbladder and lives there chronically (see Typhoid Mary). It also famous for causing rose spots on the abdomen and relative bradycardia.

Ceftriaxone is a lipid soluble third generation cephalosporin which is famous for treating a wide variety of diseases including gram negative and gram positives. Since it is lipid soluble it can cross the blood-brain barrier and is useful for the empiric treatment of meningitis. Like most lipid soluble drugs, it is metabolized by the liver and is excreted in the bile. It reaches very high concentrations in the gall bladder where is causes gallbladder sludge.

1 comment:

  1. Being a medical student i have found your blog to be truly resourceful. Great job and a big thank you to all those working to put the content up here. Much appreciated.

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