Mother of All Inducers

Barbiturates, as a class, are the most prolific inducers known, affecting almost all P450 enzymes. Inducers generally do not create drug-toxicity interactions when an inducer is added, however, on withdrawing an enzyme inducer, the resultant decrease level of enzyme will result in increased levels of drugs metabolized by these enzymes and could result in severe toxicity.

DDx of Positional Headaches

Two conditions that cause positional headaches are:

1. Colloid Cysts in the third ventricle which block the Foramen of Monro when a person changes position.

2. Post-spinal tap headache. Make sure the patient lies flat after the procedure.