Paraneoplastic Syndromes

Etiology
(++ = strong association; + = reported association)

Endocrine
Cushing's syndrome
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +

Gonadotropin excess
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +
  • Gastrointestinal cancers: +
  • Gestational trophoblastic disease: +
  • Renal cell cancer: +
  • Carcinoid: +

Hypercalcemia
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Multiple myeloma: +
  • Lymphoma: +
  • Prostate cancer: +

Hyperthyroidism
  • Gestational trophoblastic disease: +

Hypoglycemia
  • Gastrointestinal cancers: +
  • Hepatocellular cancer: +

SIADH
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +


Neuromuscular
Dermatomyositis/polymyositis
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Gastrointestinal cancers: ++
  • Ovarian cancer: +
  • Myeloproliferative disease: +

Lambert-Eaton syndrome
  • Small-cell lung cancer: ++
  • Breast cancer: +
  • Gastrointestinal cancers: +
  • Ovarian cancer: +

Sensorimotor peripheral neuropathy
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +

Stiff man syndrome
  • Breast cancer: +
  • Ovarian cancer: +

Subacute cerebellar degeneration
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +
  • Gastrointestinal cancers: +
  • Lymphoma: +
  • Ovarian cancer: +


Skin
Acanthosis nigricans
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Gastrointestinal cancers: +
  • Carcinoid: +
  • Prostate cancer: +
  • Myeloproliferative disease: +

Dermatomyositis
  • Small-cell lung cancer: ++
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Gastrointestinal cancers: ++
  • Ovarian cancer: +
  • Myeloproliferative disease: +

Sweet's syndrome
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Gastrointestinal cancers: +
  • Lymphoma: ++
  • Renal cell cancer: +
  • Ovarian cancer: +
  • Prostate cancer: +
  • Myeloproliferative disease: ++


Hematologic
Coagulopathy
  • Breast cancer: +
  • Lymphoma: +
  • Renal cell cancer: +
  • Carcinoid: +
  • Prostate cancer: +
  • Myeloproliferative disease: +

Eosinophilia
  • Lymphoma: ++

Erythrocytosis
  • Hepatocellular cancer: +
  • Renal cell cancer: +
  • Ovarian cancer: +
  • Adrenocortical tumors: +
  • Cerebellar hemangioblastomas: +

Pure red cell aplasia
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Gastrointestinal cancers: +
  • Lymphoma: +
  • Thymoma: ++

Thrombocytosis
  • Small-cell lung cancer: +
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Multiple myeloma: +
  • Gastrointestinal cancers: +
  • Hepatocellular cancer: +
  • Gestational trophoblastic disease: +
  • Lymphoma: +
  • Renal cell cancer: +
  • Carcinoid: +
  • Thymoma: +
  • Ovarian cancer: +
  • Prostate cancer: +
  • Myeloproliferative disease: +
  • Adrenocortical tumors: +
  • Cerebellar hemangioblastomas: +


Fever
  • Small-cell lung cancer: +
  • Non-small-cell lung cancer: +
  • Breast cancer: +
  • Multiple myeloma: +
  • Gastrointestinal cancers: +
  • Hepatocellular cancer: +
  • Gestational trophoblastic disease: +
  • Lymphoma: +
  • Renal cell cancer: +
  • Carcinoid: +
  • Thymoma: +
  • Ovarian cancer: +
  • Prostate cancer: +
  • Myeloproliferative disease: +
  • Adrenocortical tumors: +
  • Cerebellar hemangioblastomas: +


Amyloidosis
  • Multiple myeloma: +
  • Lymphoma: +
  • Renal cell cancer: +

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